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Harvard-trained oncologist Dr. John Frangioni is bringing cutting-edge cancer treatment to Southwest Florida. His company, Curadel Pharma, plans a 43,000-square-foot facility in Estero offering advanced targeted alpha therapy to patients from around the globe. The two-phase project aims to combine world-class care with an upscale, patient-focused experience.

Fresh Catch Bistro, PJK Neighborhood Chinese Restaurant and Real Seafood Co. are launching upscale casual restaurants in units previously home to TGI Fridays, The Saloon and Bokamper’s Sports Bar & Grill, respectively.